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GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16
Key Points: Life Biosciences, a biotech company co-founded by Harvards David Sinclair, received the FDAs permission to start a clinical trial of a gene therapy designed to rejuvenate dying cells
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The most commonly reported side effects of L-carnitine supplements are gastrointestinal, including nausea, stomach cramps, diarrhoea, and a distinctive fishy body odour caused by the production of trimethylamine during gut metabolism
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